In the 1920s in Argentina, Antonio Nores Martinez set out to breed the ultimate big game hunting dog, a dog not only capable of taking on dangerous game such as wild boar and cougars, but a dog also capable of being a loyal pet and family guardian.

Martinez picked the Cordoba Fighting Dog to be the base for the breed. This breed is extinct today but was described as a large and ferocious dog that was both a great hunter and fighter.

He crossed it with Great Dane for size. Boxer for its agility. Spanish Mastiff for power. English Bulldog for its boldness and courage. Great Pyrenees for its white coat. Bull Terrier for tenacity. Pointer for scenting ability. Irish Wolfhound for sight, and finally, the Dogue de Bordeaux for jaw strength.

Martinez kept improving the resulting breed via selective breeding to introduce the desired traits.